At long last, there is peace across the Andromeda galaxy. Angela Frye was defeated and has been sentenced to life imprisonment for her crimes against humanity. Any of her loyal supporters that survived have also been put to trial, facing various charges for following Angela till the end.
A new Head of the Senate has recently been appointed, Cassius Locke, whose job it is to continue to repair the rift between the Alliance and the Wilds. Each of the Wilds planets and the Deep Wilds have their own representative in the Senate, making sure that they sit in on important debates, and that nothing like the War of the Wilds happens again.
The Outlanders have been pardoned and are now allowed to return to the Alliance. Anyone who was injected with the Super Serum either has to take the cure or be forced to serve a life in the military or with a secret agency -- it is the only way they can justify their continuing existence. Hunters have been re-tasked with helping to keep the peace.
With everything going so right, the question is: what could possibly go wrong?